The process of detoxification is one of the chief roles of the liver. It works to convert fat-soluble substances into water soluble substances that can be excreted from the body. It does this via a two-step process designated phase I and phase II. When the function of the liver is sub-optimal, toxins can build up and poison the body. The liver detoxification profile evaluates the ability of an individual to process various toxin types by exposing them to caffeine, aspirin (salicylate) and paracetamol (acetaminophen) and assessing the metabolites present in their salivary and urinary specimens.
This test is different from standard liver function tests which only provide a measure of hepatic damage (released hepatic enzyme levels). In contrast, the liver detoxification test is a true functional test as it evaluates the ability of an individual to process caffeine, aspirin (salicylate) and paracetamol (acetaminophen) by assessing certain metabolites in salivary and urinary specimens. Specific measurements of the different phases of liver detoxification including phase I and phase II (glycination, glucuronidation, sulphation and glutathionation) are obtained which can then be used to guide the design of effective and specific therapeutic strategies to optimise liver function.
Common Conditions related to Phase 1 and Phase 2 Detoxification Imbalance:
- Chronic fatigue
- Food intolerance
- Multiple chemical sensitivities
- Hormonal imbalances
- Multiple drug therapy
Phase I: Caffeine Clearance; Phase 2: Acetaminophen glucuronide (glucuronidation), Salicyluric acid (glycination), Acetaminophen mercapturate (glutathionation), Acetaminophen sulphate (sulphation).
For test costs and to get a test kit please call us on 06 379 7705.